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“My long-term goal is to model the pathways involved in human aging in order to develop therapeutic interventions. I organize an annual aging conference in the Midwestern United States with the dual goal of promoting the aging as an adaptation theory and promoting the aging as a disease mindset. The conference website is curing-aging.com.”
Check out these other great views as well:
Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4
Interview with George Church: https://youtu.be/yNplpykf0B4
Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OM
Interview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05Q
Interview with Nir Barzilai : https://youtu.be/LuOAShcjOt0
Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8.
PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH
RSS: https://www.learningwithlowell.com/feed/podcast/
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Website: https://www.learningwithlowell.com
David Katz links
https://www.linkedin.com/in/davidwarrenkatz/
https://www.youtube.com/watch?v=zhbOo_INMwg&t=65s&ab_channel=CuringAging
https://www.curing-aging.com/
Timestamps
00:00 start
00:20 Programed aging hypothesis explained
01:20 Michael Levin / bioelectricity
02:15 Telomerase / concerns around copies of copies
04:15 Ability for immortality in animals
04:44 Immortal jellyfish
06:02 Butterfly brains
06:40 Programmed aging in practice for therapies
07:16 FDA aging as a disease
08:33 Curing aging objectionable
09:15 We need to work against our bodies
10:18 Fasting / Michael Rae / Caloric restriction
11:55 Highly against Richard Dawkins selfish gene and ideas around evolution
13:20 Start of slides
13:50 Why do we age / David’s argument
18:20 Different types of aging
23:20 Induce damage to test hypothesis
25:10 David St Clair work
26:20 Evolution has consistently selected for aging
29:20 Aging and cancer
30:00 exponential population growth
31:00 Evolution as an ecological thing
32:00 Animals getting bigger and smaller on small island / evolution as multivariable equation
35:11 Mole Rats and rats
36:25 people who get castrated live longer
37:22 Bryan Johnson / interfering with body
38:00 Testosterone / women live longer
39:22 Mechanism of the body working against itself
40:15 Easy interventions / keeping track of time for puberty, death, etc
44:30 Squirrels having a year long internal clock
46:00 Uniform life events / aging clock / evidence that convinces people
50:50 ATF4 Pathway / muscle mass
52:00 Not even trying to make therapies ATF4
54:40 Developing therapies against the body
55:30 VCs at conference
56:10 Exploring this hypothesis
58:40 Tricking body to “think” it’s younger
59:10 Aubrey De Grey like hallmarks of aging clock
1:00:00 Epigenetic clocks / biologic clocks
01:01:30 Disrupting dreams / sleep
01:02:50 Sleep affecting aging
01:04:08 People who stop sleeping die within a number of weeks
01:04:40 Does the biological clock have state and turning it back
01:10:20 Steel man argument against the Programed aging hypothesis
01:10:55 A good case for the clock / time of day, year, and stage of year
01:13:00 Dolphins and sleep
01:13:30 Target therapy with this theory
01:15:40 Children’s hospital
01:16:05 Kids better able to fight off cancer / medicine divided
01:17:11 PhD Tensor decomposition presentation / fundamental relationship of matrices
01:18:40 implications and pushback for the tensor decomposition
01:19:30 What are the trade offs / stop measuring algorithms based off complexity
01:21:18 Real life example / chromosomes
01:24:30 SENS and the human genome like project to finding the clock
01:25:11 Debating hypothesis / argument by lack of imagination
01:26:55 Evidence of lifespan clock
01:28:22 People he needs to help hunt the clock
01:29:40 Conference and post doc life
01:30:55 SENS Lisa Fabiny
01:31:40 Illinois economy of over 1 trillion dollars
01:31:55 Other great people to keep an eye out for
01:33:00 Greg Fahy
01:33:45 Book recommendations
01:34:00 Thank you for all the fish