Cholesterol Longevity Startup Creating Custom Engineered Cyclodextrins | Dr. Matthew ‘Oki’ O’Connor -140

November 8, 2022

Everything you wanted to know about longevity, cholesterol,  aging, and the brain and heart connection, but were afraid to ask.

About Oki

“Dr. O’Connor was awarded his master’s degree in neuroscience from Northwestern Medical in 1999 and his Ph.D. in Biochemistry from Baylor College of Medicine in 2005. His postdoctoral research includes work at UC Berkeley on muscle stem cells and aging. He is the former VP of Research at SENS Research Foundation where he oversaw a broad swath of research projects spanning many aspects of rejuvenation biotechnology from which he authored many papers and patents.”

Specialties: Aging research, cyclodextrin, oxidized cholesterol, mitochondria, telomeres, IND enabling drug dev.

Links

https://www.linkedin.com/company/underdogpharmaceuticals/
https://www.facebook.com/Underdog-Pharmaceuticals-106943334091737/
https://twitter.com/UnderdogPharma

PODCAST INFO:

The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.

LINKS

Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q

Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA

Linkedin: https://www.linkedin.com/in/lowell-thompson-2227b074

Twitter: https://twitter.com/LWThompson5

Website: https://www.learningwithlowell.com/

Podcast email: lowell@learningwithlowell.com

Timestamps

00:00 Start of interview with Dr. Matthew ‘Oki’ O’Connor

00:50 Alzhiemers Gene

02:40 Data cholesterol & Alzhiemers rates

04:20 Aging therapy that affects multiple illnesses 

10:20 Team needs to execute at Cyclarity Therapeutics

14:20 Keep longevity team rowing in same direction at Cyclarity Therapeutics

17:00 His role in meetings

19:20 Oxidized Cholesterol types 

23:30 Bad types of oxidized cholesterol and the effects it has on the cell

25:20 Level changes of oxidized cholesterol with age

27:10 How body handles oxidized cholesterol

28:00 Size of issue

32.30 Cyclarity Therapeutics’s therapy custom-engineered cyclodextrins and it’s effects on oxidized cholesterol

34:00 Custom-engineered cyclodextrins administration (Cyclarity Therapeutics therapy)

35:00 Future administration thoughts

36:00 Regulatory fun

39:00 What’s left before clinical trials next year?

40:20 Prepared him to lead Cyclarity Therapeutics

43:00 Imposter Syndrome 

47:00 Dream of saving billions of lives

49:00 Scaling/Executing – changes in going from concept, to clinical trials, to production

54:00 Where custom-engineered cyclodextrins are made

56:00 Scientists know no boundaries 

58:00 Vertical/Horizontal integration

59:20 Books and resources from Dr. Matthew ‘Oki’ O’Connor

1:02:00 My recommendations to him

1:02:20 Advice for people wanting to get into longevity

1:05:20 Personal longevity practices

1:07:20 Things people get caught up on

1:09:20 Stem cells

1:12:00 Staying on cutting edge

1:15:20 How to stay up to date with Dr. Matthew ‘Oki’ O’Connor, Cyclarity Therapeutics, and their development of Custom-engineered cyclodextrins

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