Aubrey De Grey:longevity escape velocity, longevity, mouse rejuvenation, Altos Labs, Yamanaka factor – 148

January 3, 2023

Aubrey De Grey discusses the progress and potential of therapies related to his ideas on anti-aging medicine, including the four therapies that will be tested in a mouse rejuvenation trial. He also shares his thoughts on partnering with organizations and individuals in the field, integrating AI into his work, and the importance of structure in maximizing impact. Aubrey De Grey discusses the potential for Yamanaka factors to be used in organ rejuvenation, and the role of transcription factors in creating induced pluripotent stem cells. He also provides advice for those interested in getting involved in the field and shares his views on time management and productivity. Aubrey De Grey discusses the potential for reversing the pathology of aging to address mechanical issues and mentions promising research being conducted by MAIA Biotechnology on cancerous cells that express telomerase. He also expresses his optimism about the possibility of reaching “longevity escape velocity” within the next 15 years.

Youtube:

Aubrey De Grey links

https://twitter.com/aubreydegrey?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor
https://www.levf.org
https://www.linkedin.com/in/aubrey-de-grey-24260b

PODCAST INFO:

The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.

LINKS

Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q

Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA

Linkedin: https://www.linkedin.com/in/lowell-thompson-2227b074

Twitter: https://twitter.com/LWThompson5

Website: https://www.learningwithlowell.com/

Podcast email: lowell@learningwithlowell.com

Timestamps

00:00 Start

01:00 Mark Hamaleinen write in question: Why we still don’t have any therapies based on his ideas published 20 years ago in his breakout paper

04:30 update on escape velocity. 50% in 15 years.

08:30 Experiments on mice

12:00 Yamanaka factor thoughts, current research on mice continued

14:30 Lev foundation research expanded and explained

16:30 Lev foundation thesis compared to others 

21:00 Hardships being at the tip of the innovation field of longevity

23:45 Open source, non profits, lev foundation

26:00 Ideas from previous organizations (ie. SENS) applied in LEV

27:15 Ichor therapeutics, and partnership process of LEV

29:30 Next generation mentorship

30:30 Summer internship program

32:45 Bullish on longevity

33:30 AI role in longevity

35:55 Anything fundamental making longevity therapies only for the rich

38:30 Longevity surgery therapies

39:30 Advice for people

40:30 Bottlenecks of longevity

42:00 Books!

43:05 Staying on cutting edge/ learning

44:15 Current curiosity and fascination

46:45 What happiness means to him and how he optimizes for it

48:30 how he stays healthy over the years, longevity practices he uses

51:45 How much money does he and the space need

52:55 Anything stopping him from getting Jeff Bezos and other high network people to invest or donate

51:55 Thoughts on altos labs & calico labs

56:35 up and coming people that inspire him (crypto people, michael levin)

59:00 Finding up and coming people to work with and for (advice)

60:30 Things people get wrong and what people ask him about longevity

1:01:35 Aubrey newsletter and updates ( news suggestions)

1:03:30 Question he wonders about that doesn’t have answer to

1:04:15 How he maximizes his day and stays productive

1:05:15 Thoughts on MAIA Biotechnology, telomerase, short vs long 

1:09:30 Final thoughts on lev foundation.

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