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The next part in a series I’ve been doing on anti-aging researchers and research. The George Church and Nichola Conlon episodes already up. In this episode focuses on Mitochondria – we get into hurtles and problems with Mitochondria, next generation doping with Mitochondria , Leigh Syndrome (Mitochondria disease), allotopic expression. and more in under 30 minutes.
Dr. Matthew O’Connor
“Matthew was awarded his Master’s degree at Northwestern Medical in 1999 for his work studying behavioral neuroscience in aged rodents. In 2005, at Baylor College of Medicine he received a PhD in Biochemistry for his work on proteins that regulate human telomeres. Postdoctoral research includes work at UC Berkeley on muscle stem cells and aging. Since 2010, Dr. O’Connor has headed up the MitoSENS project at the research center in Mountain View, California. His research is focused on “allotopic expression” of mitochondrial genes where his team is engineering mitochondrial genes to be expressed from the nucleus and targeted to the mitochondia. Since 2012 Dr. O’Connor has had broad oversight over many areas of research at SRF. Matthew O’Connor is passionate about performing basic research to combat the diseases and disabilities of aging.” Source
SENS
“SENS Research Foundation (SRF) is a 501(c)3 non-profit organization focused on transforming the way the world researches and treats age-related disease. SRF focuses on a damage repair paradigm for treating the diseases of aging, which it advances through scientific research, advocacy and education. SENS Research Foundation supports research projects at universities and institutes around the world with the goal of curing such age-related diseases as macular degeneration, heart disease, cancer, and Alzheimer’s disease. Educating the public about how we can solve the economic and political issues stemming from an aging world population and training researchers to support a growing regenerative medicine field are also major endeavors of the organization that are being accomplished though advocacy campaigns and educational programs.”
Links
Key terms from episode
- Phineas Gage
- Leigh syndrome
- mitochondria
- MT-ATP8 gene
- MT-ATP6 gene
- genetic engineering
- gene therapy
- Nuclear DNA (nDNA), or nuclear deoxyribonucleic acid
- Nuclear genome
- assays
- molecular biology
- RNA
- Proteins
- antigen
- electron transportation train
- allotopic expression
- Free Radical DNA danger
- CRISPR
- Bodybuilding
- Next generation doping
Hyperlinked Time Stamped Show notes
- 3:08 He explains how they use dysfunction/diseases to understand the function of ageing
- 4:20 He explains how the mitosens project has gone, the key discoveries, and the future of the research.
- 5:51 He explains the challenges he, and the SENS, team are facing.
- 9:48 He explains how you go about refining genetic engineering targeting (not like shooting a star wars torpedo into the death star)
- 13:58 He explains how long to build the skills to be effective by discussing the SENS internship program and the results people participating generate.
- 17:08 He explains the controversy around allotopic expression
- 20:33 He explains the benefits of moving mitochondria to the nucleus, and why it’s hard to do that.
- 23:08 He explains the benefits of supercharging mitochondria, and we get into how it could potentially be used in body building as a next generation doping mechanism.
- 26:08 He describes how they are seeking to help people with Leigh Syndrome
Amazing article, really helpful about anti-aging