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Nicholas Goldner, PhD, is the CEO and co-founder of resistanceBio, where he leads a mission to outsmart cancer by developing innovative therapies targeting treatment resistance mechanisms. He also serves as a venture partner at Pioneer Fund, actively investing in and supporting early-stage founders solving complex problems with science and technology. With a distinguished academic background, including a PhD in Molecular Cell Biology from Washington University in St. Louis, Nicholas combines scientific expertise with entrepreneurial prowess to create impactful solutions for pressing health challenges.
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Over 321 books from 170 plus interviews over 5 years
PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH
RSS: https://www.learningwithlowell.com/feed/podcast/
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Website: https://www.learningwithlowell.com/
Nicholas Goldner links
Timestamps
00:00 Introducing Nicholas Goldner and ResistanceBIO
00:30 Saving 600,000 people a year
01:30 ENCER models for pharma
04:30 Importance of ResistanceBIO to understanding cancer
05:40 Why cancer comes back / resistance mechanisms
07:30 Cure vs treatment
09:00 Cancer is natural
10:30 Full ResistanceBIO platform explained
14:55 Last 3 years of development
17:30 Knowing they were on the right path, supportive data, and deeper understanding
24:50 Business incentive and business model explained
28:30 Hiding cure for cancer myth
31:00 Diagnostic potential
32:30 Last things pharma is looking for from them
34:30 Confidence in targeting/ therapy
35:45 Platform helping understand why failures happen
38:00 Adding 10,000,000,000 years of life
40:20 Nerding out and coffee
41:20 Headache caffeine
41:55 Looking to hire – cell culture scientist work
43:55 Key experiences that will translate into the role
45:55 Cellular agriculture / specialization
48:10 How do ENCER models differ from CRISPR, Organoids, and Animal models in terms of simulating resistance (FanQ)
54:30 What is left to do / what he needs help with
58:45 Immunotherapy and landscape change for cancer treatment and cure
01:01:40 Next 5 years and Lowell offers to chase Nick
01:03:50 Handling burnout and mental health
01:07:40 Art / being creative / painting
01:12:05 What books is he reading and what he recommends
01:14:23 Foundation apple tv show
01:15:10 Retirement for Nick
01:16:55 Police brutality episode https://www.youtube.com/watch?v=WgKBIb6Zb5c
01:17:40 Non resistance life